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Mechanistic Characterization of Uterine Pain (MCUP)

Who- Individuals ages 18-45 with regular menstrual cycles who either have painful periods, uterine fibroids, endometriosis, or those with none of the above to participate as healthy controls. You cannot have an IUD to participate in this study

Why- We hope to study the physiological cause of menstrual pain and learn why a common over the counter NSAID may or may not help with cramping pain 


Where- Department of Gynecology at Evanston Hospital, right off the Central stop on the CTA Purple line


What- This study is observing how MRI technology can be used to learn more about painful periods, and how naproxen (Aleve) can help people manage their menstrual pain. The study involves 3 in-person visits: A 2-hour screen visit which will include filling out questionnaires and sensory tests, and 1-2 separate 4.5-hour MRI visits during your period that include taking either naproxen or a placebo drug. Participants must abstain from taking painkillers 8-12 hours before each MRI visit.


Compensation- Up to $350-375 compensation is possible.


To participate, please click the link below to fill out our online prescreen.

You can also reach us at 847-570-2622 or at

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