Mechanistic Characterization of Uterine Pain (MCUP)

Who- Individuals ages 18-45 with regular menstrual cycles who either have painful periods, uterine fibroids, endometriosis or who have none of the above to participate as healthy controls. You cannot have an IUD to participate in this study

Why- We hope to study the physiological cause of menstrual pain and learn why a common over the counter NSAID helps or may not help with cramping pain 

Where- Department of Gynecology at Evanston Hospital, right off the Central stop on the CTA Purple line

What- This study is observing how MRI technology can be used to learn more about painful periods and how naproxen (Aleve) can help people manage their menstrual pain. The study involves 3 visits: A 2 hour screen visit which will include filling out questionnaires and sensory tests and 2 separate 4-5 hour MRI visits on a participant’s menses that include taking either naproxen or a placebo drug. Participants must abstain from taking painkillers 8-12 hours before each MRI visit.

Compensation- Up to $350-375 compensation is possible.

To participate, please call 847-570-2622 or email

or click the link below to fill out our online questionnaire